Effect of Interferon- in Experimental Cryptosporidium parvum Infection

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Cryptosporidium parvum and Cryptosporidium andersoni infection in naturally infected cattle of northwest Iran

The protozoan intestinal parasite Cryptosporidium commonly infects cattle throughout the world and Iran. The present study was undertaken to determine the abundance and associated risk factors of Cryptosporidium infection in cattle herds of northwestern Iran. A total number of 246 fecal samples from 138 (56.1%) diarrheic (D) and 108 (43.9%) non-diarrheic (ND) cattle were rando...

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The effect of cotrimoxazole on experimental Cryptosporidium parvum infection in kids.

The prophylactic and therapeutic effects of the folic acid inhibitor cotrimoxazole (trimethoprim in combination with sulfamethoxazole) was tested in goat kids experimentally infected with Cryptosporidium parvum oocysts. Of the twenty-four 6-day-old kids inoculated with 6 x 10(6) oocysts of C parvum, ten kids were administered cotrimoxazole prophylactically at a dose 20 mg/kg per day of trimetho...

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Cryptosporidium parvum infection in experimentally infected mice: infection dynamics and effect of immunosuppression.

The effect of mouse strain, age, sex, and the size of infective dose on the susceptibility to infection with the coccidium Cryptosporidium parvum Tyzzer, 1912 was determined using several murine models. Mice were infected with C. parvum oocysts originally of cervine origin, maintained by repeat passage in calves. All mice in the experimental groups proved susceptible to infection, though this r...

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Strategies for the control of Cryptosporidium parvum infection in calves.

Cryptosporidium parvum is a protozoan parasite that is now recognized as one of the leading causes of diarrhea in young calves. To date, there are no drugs or preventive measures available for the control of this disease. We have developed an oral vaccine that, when given to calves at birth, protects against experimental challenge with C. parvum. However, when field tested on a large dairy oper...

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Transforming growth factor beta1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans.

Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta1 (TGF-beta1). None of the prechallenge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests tha...

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ژورنال

عنوان ژورنال: Journal of Infectious Diseases

سال: 1996

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/174.1.229